Severe acute respiratory coronavirus-2 (SARS-Co-2) is the causative agent of coronavirus disease-2019 (COVID-19). COVID-19 is a disease with highly variable phenotypes, being asymptomatic in most patients. In symptomatic patients, disease manifestation is variable, ranging from mild disease to severe and critical illness requiring treatment in the intensive care unit. The presence of underlying cardiovascular morbidities was identified early in the evolution of the disease to be a critical determinant of the severe disease phenotype. SARS-CoV-2, though a primarily respiratory virus, also causes severe damage to the cardiovascular system, contributing significantly to morbidity and mortality seen in COVID-19. Evidence on the impact of cardiovascular disorders in disease manifestation and outcome of treatment is rapidly emerging. The cardiovascular system expresses the angiotensin-converting enzyme-2, the receptor used by SARS-CoV-2 for binding, making it vulnerable to infection by the virus. Systemic perturbations including the so-called cytokine storm also impact on the normal functioning of the cardiovascular system. Imaging plays a prominent role not only in the detection of cardiovascular damage induced by SARS-CoV-2 infection but in the follow-up of patients’ clinical progress while on treatment and in identifying long-term sequelae of the disease.
【저자키워드】 COVID-19, SARS-CoV-2, myocarditis, Cardiovascular disorders, Takotsubo cardiomyopathy, Thromboembolism, Positron emission tomography, 【초록키워드】 Treatment, coronavirus disease, Evolution, Cytokine storm, coronavirus, intensive care, SARS-COV-2 infection, Infection, intensive care unit, cytokine, cardiovascular system, outcome, virus, coronavirus disease-2019, Symptomatic patients, Asymptomatic, respiratory virus, imaging, morbidity, Cardiovascular disorders, phenotype, Mild, morbidity and mortality, Follow-up, receptor, respiratory, angiotensin-converting enzyme-2, disease, Critical, patients, Mild disease, binding, Angiotensin-converting enzyme, Coronavirus-2, angiotensin, severe disease, Perturbation, systemic, causative agent, Phenotypes, Most patients, severe acute respiratory coronavirus, cardiovascular damage, disease manifestation, cardiovascular morbidities, SARS-Co, Severe acute respiratory coronavirus-2, significantly, the disease, cause, expresse, cardiovascular disorder, cardiovascular morbidity, 【제목키워드】 cardiovascular, pathophysiology, clinical evidence,