[저자] Joseph Fokam, Rene Ghislain Essomba, Richard Njouom, Marie-Claire A. Okomo, Sara Eyangoh, Celestin Godwe, Bryan Tegomoh, John O. Otshudiema, Julius Nwobegahay, Lucy Ndip, Blaise Akenji, Desire Takou, Mohamed M. M. Moctar, Cleophas Kahtita Mbah, Valantine Ngum Ndze, Martin Maidadi-Foudi, Charles Kouanfack, Sandrine Tonmeu, Dorine Ngono, John Nkengasong, Nicaise Ndembi, Anne-Cecile Z. K. Bissek, Christian Mouangue, Chanceline B. Ndongo, Emilienne Epée, Nadia Mandeng, Sandrine Kamso Belinga, Ahidjo Ayouba, Nicolas Fernandez, Marcel Tongo, Vittorio Colizzi, Gregory-Edie Halle-Ekane, Carlo-Federico Perno, Alexis Ndjolo, Clement B. Ndongmo, Judith Shang, Linda Esso, Oliviera de-Tulio, Moussa Moise Diagne, Yap Boum, Georges A. E. Mballa, Louis R. Njock, Genomic Surveillance Study GroupMbaSerge Alain Sadeuh7NgoupouPaul-Alain Tagnoukam7HenriMoumbeket Yifomnjou7EyoumBertrand2BeloumouGrace3NgabaGuy Pascal2MediChristiane2NyatteLydie2SandersMelissa2AmougouMarie2BilleLoko11BuyohnwendaKizito Atehambe2NgomtchoClaudine5MouliomAbas2NjuwaFai Karl Gwei2AtebaGisele Nke2NkaAlex23DimiteLaura22DirAdama N.24EboumbouCarole17, Serge Alain Sadeuh Mba, Paul-Alain Tagnoukam Ngoupou, Moumbeket Yifomnjou Henri, Bertrand Eyoum, Grace Beloumou, Guy Pascal Ngaba, Christiane Medi, Lydie Nyatte, Melissa Sanders, Marie Amougou, Loko Bille, Kizito Atehambe Buyohnwenda, Claudine Ngomtcho, Abas Mouliom, Fai Karl Gwei Njuwa, Gisele Nke Ateba, Alex Nka, Laura Dimite, Adama N. Dir, Carole Eboumbou
[Category] update2024,
[Article Type] article
[Source] pmc
While the SARS-CoV-2 dynamic has been described globally, there is a lack of data from Sub-Saharan Africa. We herein report the dynamics of SARS-CoV-2 lineages from March 2020 to March 2022 in Cameroon. Of the 760 whole-genome sequences successfully generated by the national genomic surveillance network, 74% were viral sub-lineages of origin and non-variants of concern, 15% Delta, 6% Omicron, 3% Alpha and 2% Beta variants. The pandemic was driven by SARS-CoV-2 lineages of origin in wave 1 (16 weeks, 2.3% CFR), the Alpha and Beta variants in wave 2 (21 weeks, 1.6% CFR), Delta variants in wave 3 (11 weeks, 2.0% CFR), and omicron variants in wave 4 (8 weeks, 0.73% CFR), with a declining trend over time (p = 0.01208). Even though SARS-CoV-2 heterogeneity did not seemingly contribute to the breadth of transmission, the viral lineages of origin and especially the Delta variants appeared as drivers of COVID-19 severity in Cameroon.
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【저자키워드】 Medical research, Microbiology, Molecular biology, Molecular medicine, Biotechnology, Computational biology and bioinformatics,