The potentially detrimental effects of the worldwide deficiency of Omega-3 fatty acids on the COVID-19 pandemic have been underestimated. The Omega-3 Index (O3I), clinical variables, biometric indices, and nutritional information were directly determined for 74 patients with severe COVID-19 and 10 healthy quality-control subjects. The relationships between the OI3 and mechanical ventilation (MV) and death were analyzed. Results: Patients with COVID-19 exhibited low O3I (mean: 4.15%; range: 3.06–6.14%)—consistent with insufficient fish and Omega-3 supplement consumption, and markedly lower than the healthy control subjects (mean: 7.84%; range: 4.65–10.71%). Inverse associations were observed between O3I and MV (OR = 0.459; C.I.: 0.211–0.997) and death (OR = 0.28; C.I.: 0.08–0.985) in severe COVID-19, even after adjusting for sex, age, and well-known risk factors. Conclusion: We present preliminary evidence to support the hypothesis that the risk of severe COVID-19 can be stratified by the O3I quartile. Further investigations are needed to assess the value of the O3I as a blood marker for COVID-19.
【저자키워드】 COVID-19, Inflammation, Omega-3 fatty acids, Omega-3 Index, 【초록키워드】 Risk factors, severe COVID-19, mechanical ventilation, COVID-19 pandemic, Sex, risk, Patient, death, age, information, Blood, association, marker, Evidence, Hypothesis, omega-3 fatty acid, Support, deficiency, index, clinical variables, quartile, inverse, analyzed, healthy, exhibited, subjects, stratified, detrimental effect, control subject, quality-control, the healthy, with COVID-19, 【제목키워드】 clinical, index, Result,