Introduction Studies on maternal microRNA expression have emerged to better understand regulatory mechanisms during the gestational period, since microRNA expression has been associated with pregnancy disorders. Objectives This study aims to investigate the association between the expression of the maternal microRNAs miR-let-7d-3p and miR-451a during the second gestational trimester and neuropsychomotor development at 90 days of life of infants. Methods This is a case-control study nested within a cohort, with the groups being divided into dyads in which pregnant women presented Major Depressive Episode (MDE) (n = 64), these being the cases, and their respective controls (no MDE; n = 64). The Bayley Scale III was used to assess the outcome of child development, and MDE was assessed through the Mini International Neuropsychiatric Interview Plus. The analysis of miR-let-7d-3p and miR-451a was done via serum from the pregnant women, utilizing the qRT-PCR (n = 128). Results The results indicated a negative association between expression levels of miR-451a (β −3.3 CI95% −6.4;-0.3) and a positive associated of the miR-let-7d-3p with the cognitive development domain (β 1.7 CI95% 0.1; 3.0), and a positive association between expression of miR-let-7d-3p with motor development of the infants (β 1.6 CI95% 0.3; 2.9). Conclusion This is a pioneering study on the topic that indicates a biological interrelationship between the miRNAs miR-let-7d-3p and miR-451a evaluated during the pregnancy and the motor and cognitive domains of infant development at 90 days postpartum. Graphical abstract Image 1 Highlights • The expression of maternal miR-let-7d-3p and miR-451a is associated with child development. • Negative association between maternal expression of miR-451a and child cognitive development. • Positive association between maternal expression of miR-let-7d-3p and child cognitive. • Positive association between maternal expression of miR-let-7d-3p and child motor development. • There is a biological interrelationship between the evaluated miRNAs and child development.
【저자키워드】 Pregnancy, infant development, Cognitive development, Motor development, miR-451a, miR-let-7d-3p,