The SARS-CoV-2 RNA vaccines are smartly designed to increase the synonymous codon usage by introducing multiple U-to-C mutations. This design would elevate the translation efficiency of vaccine RNAs. However, we found evidence to reason that the designed cytidines might be converted to uridines again by C-to-U RNA deamination in host cells. This C-to-U mechanism might be a main factor that affects the efficacy and safety of RNA vaccines.
All Keywords
【저자키워드】 SARS-CoV-2, Efficacy, Vaccines, Synonymous codon usage, C-to-U RNA editing,
【저자키워드】 SARS-CoV-2, Efficacy, Vaccines, Synonymous codon usage, C-to-U RNA editing,