eTOC blurb Buel et al. discover the E3 ligase E6AP AZUL to interact with the UBA of the UBQLN family of proteasome shuttle factors and a helical UBQLN UBA-adjacent domain that oligomerizes and allosterically senses AZUL binding to UBA. They further solve the AZUL:UBA structure by integrating AlphaFold2-Multimer with NMR NOESY data.
All Keywords
【저자키워드】 biomolecular condensates, AlphaFold, E3 ligase, proteasome, E6AP, UBE3A, UBQLN1/2,
【저자키워드】 biomolecular condensates, AlphaFold, E3 ligase, proteasome, E6AP, UBE3A, UBQLN1/2,