Loy et al. use cell-free RNA, whole-blood RNA, and cell-free DNA sequencing to characterize distinct host response and cellular injury profiles in pediatric patients with MIS-C and/or COVID-19. This study highlights the complementary information from cell-free and whole-blood RNA analyses, with broad implications for future liquid biopsy applications.
All Keywords
【저자키워드】 SARS-CoV-2, Coronavirus disease 2019, immune response, multisystem inflammatory syndrome in children, pediatric, Systems biology, host response, DNA damage, RNA-Seq, RNA sequencing, signaling pathways, Clinical severity, disease biomarkers, cell-free DNA, tissue damage, cell damage, bisulfite sequencing, cell-free RNA, nucleic acid sequencing, whole-blood RNA,
【저자키워드】 SARS-CoV-2, Coronavirus disease 2019, immune response, multisystem inflammatory syndrome in children, pediatric, Systems biology, host response, DNA damage, RNA-Seq, RNA sequencing, signaling pathways, Clinical severity, disease biomarkers, cell-free DNA, tissue damage, cell damage, bisulfite sequencing, cell-free RNA, nucleic acid sequencing, whole-blood RNA,