[저자] Constanza Méndez, Hernán F. Peñaloza, Bárbara M. Schultz, Alejandro Piña-Iturbe, Mariana Ríos, Daniela Moreno-Tapia, Patricia Pereira-Sánchez, Diane Leighton, Claudia Orellana, Consuelo Covarrubias, Nicolás M.S. Gálvez, Jorge A. Soto, Luisa F. Duarte, Daniela Rivera-Pérez, Yaneisi Vázquez, Alex Cabrera, Sergio Bustos, Carolina Iturriaga, Marcela Urzua, María S. Navarrete, Álvaro Rojas, Rodrigo A. Fasce, Jorge Fernández, Judith Mora, Eugenio Ramírez, Aracelly Gaete-Argel, Mónica Acevedo, Fernando Valiente-Echeverría, Ricardo Soto-Rifo, Daniela Weiskopf, Alba Grifoni, Alessandro Sette, Gang Zeng, Weining Meng,
CoronaVac03CL Study GroupRojasÁlvaroNavarreteMaría SoledadDel RíoConstanzaDel PinoDinelyAguirreNataliaSalinasGreciaVegaFrancoSalgadoAcsaQuinterosThomasOrtizMarlenePuenteMarcelaMuñozAlmaAstudilloPatricioLe CorreNicolePotinMarcelaCatalánJuanPeraltaMelanZamanilloConsueloKellerNicoleFernándezRocíoAljaroSofíaLópezSofíaGonzálezJosé TomásWeilTaniaOpazoLuzMuñozPaulaEstayInésCantillanaMiguelCarreraLilianaMasallerasMatíasGuzmánPaulaAguirreFranciscaCortésAarónBátizLuis FedericoPérezJavieraApablazaKarenYatesLorenaValdésMaría de los ÁngelesHurtadoBernarditaVenteneulVeroniqueAstorgaConstanzaMuñoz-VenturelliPaulaVialPablo A.SchillingAndreaPavezDanielaPérezIniaRiviottaAmyGonzálezFranciscaUrrutiaFranciscaDel RíoAlejandraAsenjoClaudiaVargasBárbaraCastroFranciscaAcuñaAlejandraGuzmánJavieraAstudilloCamilaPérezCarlos M.EspinozaPilarMartínezAndreaArancibiaMarcelaRomeroHaroldBustamanteCeciliaPérezMaría LoretoUribeNataliaSilvaVivianaMoriceBernarditaPérezMarcoGonzálezMarcelaJensenWernerPastenClaudiaAguileraM. FernandaMartínezNatalyMolinaCamilaArrietaSebastiánLópezBegoñaOrtizClaudiaEscobarMacarenaBustamanteCamilaEspinozaMarciaPardoAngelaCarrascoAlisonMontesMiguelSaldíasMacarenaGutiérrezNataliaSánchezJulietteFuentesDanielaCalvoYolandaCepedaMarielaLemusRosarioSuárezMurielArmijoMercedesMonsalvesShirleyMarucichConstanceCornejoCeciliaAcostaÁngelaPradoXavieraYáñezFranciscaBarroetaMarisolLópezClaudiaDonatoPaulinaLassoMartinIturrietaMaríaGiraldoJuanGutiérrezFranciscoAcuñaMaríaCasconeAdaRojasRaymundoSepúlvedaCamilaContrerasMarioCampistoYessicaGonzálezPabloQuizhpiZoilaLópezMariellaPizzeghelloVaniaSilvaStephannie
, Álvaro Rojas, María Soledad Navarrete, Constanza Del Río, Dinely Del Pino, Natalia Aguirre, Grecia Salinas, Franco Vega, Acsa Salgado, Thomas Quinteros, Marlene Ortiz, Marcela Puente, Alma Muñoz, Patricio Astudillo, Nicole Le Corre, Marcela Potin, Juan Catalán, Melan Peralta, Consuelo Zamanillo, Nicole Keller, Rocío Fernández, Sofía Aljaro, Sofía López, José Tomás González, Tania Weil, Luz Opazo, Paula Muñoz, Inés Estay, Miguel Cantillana, Liliana Carrera, Matías Masalleras, Paula Guzmán, Francisca Aguirre, Aarón Cortés, Luis Federico Bátiz, Javiera Pérez, Karen Apablaza, Lorena Yates, María de los Ángeles Valdés, Bernardita Hurtado, Veronique Venteneul, Constanza Astorga, Paula Muñoz-Venturelli, Pablo A. Vial, Andrea Schilling, Daniela Pavez, Inia Pérez, Amy Riviotta, Francisca González, Francisca Urrutia, Alejandra Del Río, Claudia Asenjo, Bárbara Vargas, Francisca Castro, Alejandra Acuña, Javiera Guzmán, Camila Astudillo, Carlos M. Pérez, Pilar Espinoza, Andrea Martínez, Marcela Arancibia, Harold Romero, Cecilia Bustamante, María Loreto Pérez, Natalia Uribe, Viviana Silva, Bernardita Morice, Marco Pérez, Marcela González, Werner Jensen, Claudia Pasten, M. Fernanda Aguilera, Nataly Martínez, Camila Molina, Sebastián Arrieta, Begoña López, Claudia Ortiz, Macarena Escobar, Camila Bustamante, Marcia Espinoza, Angela Pardo, Alison Carrasco, Miguel Montes, Macarena Saldías, Natalia Gutiérrez, Juliette Sánchez, Daniela Fuentes, Yolanda Calvo, Mariela Cepeda, Rosario Lemus, Muriel Suárez, Mercedes Armijo, Shirley Monsalves, Constance Marucich, Cecilia Cornejo, Ángela Acosta, Xaviera Prado, Francisca Yáñez, Marisol Barroeta, Claudia López, Paulina Donato, Martin Lasso, María Iturrieta, Juan Giraldo, Francisco Gutiérrez, María Acuña, Ada Cascone, Raymundo Rojas, Camila Sepúlveda, Mario Contreras, Yessica Campisto, Pablo González, Zoila Quizhpi, Mariella López, Vania Pizzeghello, Stephannie Silva, José V. González-Aramundiz, Pablo A. González, Katia Abarca, Felipe Melo-González, Susan M. Bueno, Alexis M. Kalergis
[Category] update2024,
[Article Type] Article
[Source] PMC
Summary Background The Omicron variant has challenged the control of the COVID-19 pandemic due to its immuno-evasive properties. The administration of a booster dose of a SARS-CoV-2 vaccine showed positive effects in the immunogenicity against SARS-CoV-2, effect that is even enhanced after the administration of a second booster. Methods During a phase-3 clinical trial, we evaluated the effect of a second booster of CoronaVac®, an inactivated vaccine administered 6 months after the first booster, in the neutralization of SARS-CoV-2 (n = 87). In parallel, cellular immunity (n = 45) was analyzed in stimulated peripheral mononuclear cells by flow cytometry and ELISPOT. Findings Although a 2.5-fold increase in neutralization of the ancestral SARS-CoV-2 was observed after the second booster when compared with prior its administration (Geometric mean units p < 0.0001; Geometric mean titer p = 0.0002), a poor neutralization against the Omicron variant was detected. Additionally, the activation of specific CD4^{+} T lymphocytes remained stable after the second booster and, importantly, equivalent activation of CD4^{+} T lymphocytes against the Omicron variant and the ancestral SARS-CoV-2 were found. Interpretation Although the neutralizing response against the Omicron variant after the second booster of CoronaVac® was slightly increased, these levels are far from those observed against the ancestral SARS-CoV-2 and could most likely fail to neutralize the virus. In contrast, a robust CD4^{+}T cell response may confer protection against the Omicron variant. Funding The Ministry of Health , Government of Chile , the Confederation of Production and Commerce, Chile and SINOVAC Biotech. 10.13039/100000002 NIH 10.13039/100000060 NIAID . The Millennium Institute on Immunology and Immunotherapy .
All Keywords
【저자키워드】 SARS-CoV-2, Humoral immunity, cellular immunity, Omicron variant, second booster dose, CoronaVac®,