Graphical Abstract 2-aminoimidazole dimers in combination with the gram-positive selective antibiotic clarithromycin provide a new approach towards combating antibiotic resistant Gram-negative infections. Macrolides typically have limited efficacy against Gram-negative bacteria due to poor permeation across the Gram-negative outer membrane. However, in the presence of 2-aminoimidazole dimers, clarithromycin becomes efficacious against several Gram-negative species including Acinetobacter baumannii .
All Keywords
【저자키워드】 adjuvants, Antibiotic resistance, Acinetobacter baumannii, outer membrane, macrolides,
【저자키워드】 adjuvants, Antibiotic resistance, Acinetobacter baumannii, outer membrane, macrolides,