A lack of biological knowledge and technical challenges limits the widespread therapeutic application of extracellular vesicles. This review summarizes current knowledge on the biogenesis and composition of exosomes and microvesicles. Moreover, it extends into natural cargo sorting and discusses how this knowledge can be harnessed to develop engineered EV biotherapeutics.
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【저자키워드】 Exosomes, Microvesicles, drug delivery, EV engineering, EV heterogeneity,
【저자키워드】 Exosomes, Microvesicles, drug delivery, EV engineering, EV heterogeneity,