Objective To estimate the seroprevalence of SARS-CoV-2 antibodies in the Valencian Community (Spain) in October 2022, when BA.5 was the predominant variant. Method Cross-sectional, region-wide, population-based serosurvey study in 88 randomly selected primary care centers of the Valencian Community. Results Seroprevalence of anti-nucleocapsid (indicative of past infection) and total receptor binding domain (indicative of past infection or vaccination) antibodies was 71.0% (confidence interval [CI]: 67.8-74.2) and 98.4% (CI: 97.5-99.3), respectively. 66.7% (CI: 63.4-70.0) of the population shows hybrid immunity, but only 43.2% in those 80 and over. Conclusions The high proportion of hybrid immunity detected is relevant for public health strategies. A second vaccination booster was advisable in the elderly population.
【저자키워드】 COVID-19, Adaptive immunity, SARS-CoV-2 variants, COVID-19 serological testing, Seroepidemiologic studies, Spain, España, Estudios seroepidemiológicos, Inmunidad adaptativa, Pruebas serológicas de COVID-19, Variantes de SARS-CoV-2,