Highlights • Pathogenic strain of SARS-CoV-2, such as Delta, triggers the sign of ferroptosis in lung tissue of K18-hACE2 mice. • SARS-CoV-2 ORF3a sensitizes cell to ferroptosis through NRF2-ARE pathway. • SARS-CoV-2 ORF3a promotes the degradation of NRF2 via increasing the binding affinity between Keap1 and NRF2.
All Keywords
【저자키워드】 SARS-CoV-2, Ferroptosis, Nrf2, ORF3a, Keap1,
【저자키워드】 SARS-CoV-2, Ferroptosis, Nrf2, ORF3a, Keap1,