In a randomized clinical trial of 86 hospitalized COVID-19 patients comparing standard care to treatment with 300mL convalescent plasma containing high titers of neutralizing SARS-CoV-2 antibodies, no overall clinical benefit was observed. Using a comprehensive translational approach, we unravel the virological and immunological responses following treatment to disentangle which COVID-19 patients may benefit and should be the focus of future studies. Convalescent plasma is safe, does not improve survival, has no effect on the disease course, nor does plasma enhance viral clearance in the respiratory tract, influence SARS-CoV-2 antibody development or serum proinflammatory cytokines levels. Here, we show that the vast majority of patients already had potent neutralizing SARS-CoV-2 antibodies at hospital admission and with comparable titers to carefully selected plasma donors. This resulted in the decision to terminate the trial prematurely. Treatment with convalescent plasma should be studied early in the disease course or at least preceding autologous humoral response development. There are currently no drugs available to treat SARS-CoV-2 infection. A promising alternative treatment for COVID-19 patients is convalescent plasma. Here, Gharbharan et al. collect covalescent plasma and report no overall clinical benefit for 86 patients hospitalized for COVID-19 and treated with 300 mL convalescent plasma.
【저자키워드】 SARS-CoV-2, Translational research, viral infection, 【초록키워드】 COVID-19, Treatment, convalescent plasma, randomized clinical trial, Cytokines, Trial, SARS-COV-2 infection, drug, viral clearance, SARS-CoV-2 antibodies, survival, Viral, SARS-CoV-2 antibody, neutralizing SARS-CoV-2 antibody, Patient, plasma, Hospital admission, respiratory tract, donors, respiratory, proinflammatory cytokines, COVID-19 patients, Immunological response, hospitalized COVID-19 patient, COVID-19 patient, Safe, no effect, focus, Virological, standard care, decision, clinical benefit, disease course, treat, neutralizing SARS-CoV-2 antibodies, serum proinflammatory cytokines, virological and immunological responses, approach, benefit, ENhance, IMPROVE, Course, selected, the disease, treated, majority, comparable, translational, autologous humoral response, patients hospitalized, serum proinflammatory cytokine, treatment for COVID-19, 【제목키워드】 neutralizing antibody, Infection, Effect, severe SARS-CoV-2, patients hospitalized,