Vaginal epithelial dysfunction is mediated by the microbiome, metabolome, and mTOR signaling

Published on
Journal: Cell Reports
[저자] Alicia R. Berard, Douglas K. Brubaker, Kenzie Birse, Alana Lamont, Romel D. Mackelprang, Laura Noël-Romas, Michelle Perner, Xuanlin Hou, Elizabeth Irungu, Nelly Mugo, Samantha Knodel, Timothy R. Muwonge, Elly Katabira, Sean M. Hughes, Claire Levy, Fernanda L. Calienes, Douglas A. Lauffenburger, Jared M. Baeten, Connie Celum, Florian Hladik, Jairam Lingappa, Adam D. Burgener
[Category] update2024,
PMC URL    Pubmed URL    DOI URL    [DOI] 10.1016/j.celrep.2023.112474    
[Article Type] Article
[Source] PMC

Berard et al. find a key cellular central signaling network, mTOR, that associates with host inflammation and epithelial barrier disruption in women with a dysbiotic vaginal microbiome and bacterial vaginosis (BV). This network, as well as barrier disruption, is directly modulated by bacterial products and BV-associated metabolites in vitro .

All Keywords
【저자키워드】 Inflammation, metabolomics, proteomics, transcriptomics, in vitro models, Epithelial barrier, mTOR signaling, vaginal microbiome, Bacterial vaginosis, vaginal dysbiosis, BV, imidazolepropionic acid,