Spike-protein proteolytic antibodies in COVID-19 convalescent plasma contribute to SARS-CoV-2 neutralization

Published on
Journal: Cell chemical biology
[저자] Scott A. McConnell, Jaiprasath Sachithanandham, Nathan J. Mudrak, Xianming Zhu, Parsa Alba Farhang, Radames J.B. Cordero, Maggie P. Wear, Janna R. Shapiro, Han-Sol Park, Sabra L. Klein, Aaron A.R. Tobian, Evan M. Bloch, David J. Sullivan, Andrew Pekosz, Arturo Casadevall
[Category] update2024,
PMC URL    Pubmed URL    DOI URL    [DOI] 10.1016/j.chembiol.2023.05.011    
[Article Type] Article
[Source] PMC

McConnell et al. identify catalytic antibodies specific to the SARS-CoV-2 protein across a large panel of convalescent plasma donors. Antibody-mediated degradation of spike epitopes is correlated with viral neutralization capacity and catalysis is persistently observed despite antigenic drift of Spike in variant strains.

All Keywords
【저자키워드】 SARS-CoV-2, viral neutralization, antigen cleavage, catalytic antibodies,