Graphical Abstract A series of constrained α, γ-AApeptides served as a novel scaffold to design aldehydes and ketoamides to inhibit the M^{pro} of the SARS-CoV-2. They show excellent inhibitory activity against SARS-CoV-2 and broad-spectrum activity against different other HCoVs. The X-ray structure of M^{pro} with inhibitors demonstrated the mechanism of covalent inhibition of M^{pro}.
All Keywords
【저자키워드】 COVID-19, SARS-CoV-2, Mpro inhibitor, X-ray structure, Broad-spectrum activity,
【저자키워드】 COVID-19, SARS-CoV-2, Mpro inhibitor, X-ray structure, Broad-spectrum activity,