Objectives The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging virus causing substantial morbidity and mortality worldwide. We performed a cross-sectional investigation of SARS-CoV-2 clusters in Suzhou to determine the transmissibility of the virus among close contacts and to assess the demographic and clinical characteristics between index and secondary cases. Methods We review the clustered patients with SARS-CoV-2 infections in Suzhou between 22 January and 29 February 2020. The demographic and clinical characteristics were compared between index and secondary cases. We calculated the basic reproduction number ( R 0 ) among close contacts with SLI model. Results By 22 February, 87 patients with SARS-CoV-2 infection were reported, including 50 sporadic and 37 clustered cases, who were generated from 13 clusters. On admission, 5 (20.8%) out of 24 secondary cases were asymptomatic. The male ratio of index cases was significantly higher than that of secondary cases. Additionally, the index cases were more likely to have fever and increased CRP levels than the secondary cases. The R 0 values of clusters displayed a significantly declining trend over time for all clusters. The relative risk of infection in blood-related contacts of cases versus unrelated contacts was 1.60 for SARS-CoV-2 (95% CI: 0.42-2.95). Conclusions In conclusion, SARS-CoV-2 has great person-to-person transmission capability among close contacts. The secondary cases are more prone to have mild symptoms than index cases. There is no increased RR of secondary infection in blood relatives versus unrelated contacts. The high rate of asymptomatic SARS-CoV-2 infections highlights the urgent need to enhance active case finding strategy for early detection of infectious patients.
【초록키워드】 SARS-CoV-2, coronavirus, Clinical characteristics, cross-sectional, SARS-COV-2 infection, Infection, Transmission, severe acute respiratory syndrome Coronavirus, virus, Relative risk, Secondary infection, Transmissibility, Asymptomatic, Fever, Early detection, male, Clusters, Cluster, basic reproduction number, morbidity and mortality, infectious, respiratory, Admission, SARS-CoV-2 infections, patients, mild symptoms, Blood, close contact, risk of infection, Contact, index case, case finding, on admission, index, acute respiratory syndrome, Mild symptom, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, index cases, CRP levels, demographic and clinical characteristics, CRP level, secondary cases, secondary case, objective, highlight, ENhance, Result, performed, significantly, reported, calculated, determine, significantly higher, declining, patients with SARS-CoV-2, 【제목키워드】 SARS-CoV-2, coronavirus 2, China, household,