The dysregulation of lipid metabolism has emerged as a central component of many neurodegenerative diseases. Variants of the lipid transport protein, Apolipoprotein E (APOE), modulate risk and resilience for several neurodegenerative diseases including late-onset Alzheimer’s disease. APOE variants directly alter the lipid metabolism of cells and tissues and have been broadly associated with several other cellular and systemic phenotypes. Targeting APOE -associated metabolic pathways may offer opportunities to alter disease-related phenotypes and consequently, attenuate risk for and impart resilience against multiple neurodegenerative diseases. Here we review the molecular, cellular, and tissue-level alterations to lipid metabolism that arise from different APOE isoforms. These changes to lipid metabolism could help us understand disease mechanisms and tune neurodegenerative disease risk and resilience.
【저자키워드】 Alzheimer’s disease, Neurodegenerative disease, Apolipoprotein e, lipid metabolism,