Highlights • The physicochemical and mechanical properties of heparin and its derivatives are overviewed. • The biological properties of heparin and heparin-based materials including its anticoagulation ability, biodegradability, and biocompatibility are discussed. • A comprehensive review of the biomedical applications of heparin and its derivatives, including tissue regeneration, gene and drug delivery, cancer therapy, and biosensors is provided. • Insight into the future outlook of heparin and heparin-based materials research and its potential for continued innovation in biomedical applications is summarized.
【저자키워드】 heparin, biomedical applications, nanomaterials, Biological, preparation, physicochemical,