A Potent Recombinant Polyclonal Antibody Therapeutic for Protection Against New Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern

Published on
Journal: Nanoscale
[저자] Nicholas P Wayham, Ariel R Niedecken, Jan Fredrik Simons, Yao Y Chiang, Angélica V Medina-Cucurella, Rena A Mizrahi, Ellen K Wagner, Ashley Gras, Ilana Segal, Peyton Witte, Alexis Enstrom, Aristea Bountouvas, Sabrina M Nelson, Tess Weinberger, David Tan, Michael A Asensio, Alagu Subramanian, Yoong Wearn Lim, Adam S Adler, Sheila M Keating
[Category] update2024,
PMC URL    Pubmed URL    DOI URL    [DOI] 10.1093/infdis/jiad102    
[Article Type] Major Article
[Source] PMC

Emergent SARS-CoV-2 variants can evolve resistance to existing treatment modalities. A recombinant polyclonal antibody hyperimmune iteratively enriched for antiancestral and anti-omicron BA.2 receptor binding domain activity may select for neutralizing antibodies that target mutational cold spots preventing future drug resistance.

All Keywords
【저자키워드】 SARS-CoV-2, antibody, omicron, variants, hyperimmune,