TECPR1 is activated by damage‐induced sphingomyelin exposure to mediate noncanonical autophagy

Published on 2023-07-062024-09-05
Journal: The EMBO Journal

[저자] Namrita Kaur, Laura Rodriguez de la Ballina, Håvard Styrkestad Haukaas, Maria Lyngaas Torgersen, Maja Radulovic, Michael J Munson, Alan Sabirsh, Harald Stenmark, Anne Simonsen, Sven R Carlsson, Alf Håkon Lystad

[Category] update2024,

PMC URL Pubmed URL DOI URL [DOI] 10.15252/embj.2022113105

[Article Type] Article

[Source] PMC

The TECPR1‐ATG5‐ATG12 complex recognizes damage‐induced sphingomyelin exposure on endolysosomal membranes leading to ATG8ylation of damaged membranes independently of ATG16L1.

All Keywords
【저자키워드】 sphingomyelin, noncanonical autophagy, Autophagy & Cell Death, DysF, CASM, membrane damage,