Summary Nearly half of the world’s population is at risk of malaria, a disease caused by the protozoan parasite Plasmodium, that is estimated to cause more than 240,000,00 infections and kill more than 600,000 people annually. The emergence of Plasmodia resistant to chemoprophylactic treatment highlights the urgency to develop more effective vaccines. In this regard, whole sporozoite vaccination approaches in murine models and human challenge studies have provided substantial insight into the immune correlates of protection from malaria. From these studies, CD8+ T cells have come to the forefront, being identified as critical for vaccine-mediated liver stage immunity that can prevent the establishment of the symptomatic blood-stages and subsequent transmission of infection. However, the unique biological characteristics required for CD8+ T cell protection from liver-stage malaria dictate that more work must be done to design more effective vaccines. In this review we will highlight a subset of studies that reveal basic aspects of memory CD8+ T cell mediated protection from liver-stage malaria infection
【저자키워드】 malaria, Malaria vaccines, liver-stage immunity, human challenge models, CD8+ T cell immunity, mouse models of malaria,