Synthesis of Optically Active SARS-CoV-2 Mpro inhibitor drug Nirmatrelvir (Paxlovid): an Approved Treatment of COVID-19

Published on
Journal: Organic & Biomolecular Chemistry
[저자] Arun K. Ghosh, Monika Yadav
[Category] update2024,
PMC URL    Pubmed URL    DOI URL    [DOI] 10.1039/d3ob00653k    
[Article Type] Article
[Source] PMC

Graphical Abstract Synthesis of nirmatrelvir (paxlovid), an FDA approved SARS-COV-2 MPro inhibitor drug is described. The present optically active synthesis avoids a critical epimerization step.

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