Benvenisty, Wolf, and colleagues report a loss-of-function genome-wide CRISPR-Cas9 knockout screen, using haploid human embryonic stem cells and their differentiated definitive endoderm progenies, in order to identify potential novel modulators of SARS-CoV-2. Their screen was able to identify potential novel membrane and nuclear proteins with pronounced effect on viral RNA load in the supernatant of the infected cells.
All Keywords
【저자키워드】 SARS-CoV-2, Genome-wide screening, Human pluripoptent stem cells,
【저자키워드】 SARS-CoV-2, Genome-wide screening, Human pluripoptent stem cells,