Highlights • Alpaca-derived nanobodies showed a cross-neutralizing activity against SARS-CoV-2 variants. • aVHH-13-Fc provided complete protection in mild and severe COVID-19 rodent models. • The binding site between aVHH-13-Fc and the RBD variant of SARS-CoV-2 is partially located on the RBM.
All Keywords
【저자키워드】 COVID-19, SARS-CoV-2, nanobody, therapeutic, broad-spectrum, rodent models,
【저자키워드】 COVID-19, SARS-CoV-2, nanobody, therapeutic, broad-spectrum, rodent models,