[저자] Lianne de Haan, Marije ten Wolde, Martijn Beudel, Rik H G Olde Engberink, Brent Appelman, Esther K Haspels-Hogervorst, Daisy Rusch, Niels C Gritters van den Oever, Suat Simsek, Nienke Paternotte, Joop P van den Bergh, Caroline E Wyers, Martijn D de Kruif, Tom Dormans, Hazra Moeniralam, Neyma Bokhizzou, Kees Brinkman, Renee Douma,
The Dutch COVID-PREDICT study group
BeudelMartijnAppelmanBrentDoumaRenéeRuschDaisySimsekSuatBrinkmanKeesvan den OeverNiels Grittersvan den BerghJoopMoeniralamHazraBokhizzouNeymade KruifMartijnLeavisHelenPiña-FuentesDanThomasRajatArtsDerkNurmohamedNickReeskampRensHuShiHerterWillemVonkBasLopesRicardoRamosLucasHubertsDeborahWolfersMarijeSchinkelMichielde KuijSanderDormansTomNoordzijSophievan den BoschSibbelieneVerhoefBentheMethorstMicheleDarweshShahanvan EgmondTijnNasimGulsumAliHamzade BoerLarsNagelMyrtheKoenisMaudBijlsmaAgnethaBalversBrittGhauharaliIsabellade JonghJelleEmanuelMairaAynaouNisrinede RidderRosemarieDarrazInsaffDarrazOumaimaCinarAlanarRoosenJesseHeidemanLarissaLeliveldAsabiRuijterDanaRosenbergNeeltjeWoutmanDjoekeVermeulenTomde JoodeSamBergerWillemLuddenThomasVaranOzguPintoSoesjaSluisSientjeKuiperBibivan der PuttenTimBosjeDominiqueSinyangweMahundavan RhijnRoosKruifKoende HaanLianneden HeijerMiriamde KruijfKoenHofhuisSamLeliveldAsabiVermeulenTomTeltingGwendolynde BoerLarsde RidderRosemarievan der LeiSusanvan PaassenPienter VeerEmilOpschoorKrijnaBreukhovenCamilleJiwaFlorinede GooyerPeterVrijdagJanvan GelderStansPannekoekAnneDommershuijzenLauraAdangEstellevan MarenMaudKoopIsabelSandersBartWantenJoukjeTrommelenDaxSmeetsFleurHeuvelingsKyraCoxMaudRademaekersMilouHendrikxVivianvan RooijIlonaHeutsWendyOudemanLauraBransEvelienSlotKarinBoerma-ArgeloKirstenKokWilmaHarmsenLiekeBoeremaIngridPirsonAnneRaafsAnneSmaalAnnePopBibianeVerkouterenBabetteWaterinkCarmenVrijCaspervan der WillikDaphneHubersDeborahLemsEstherReitsmaFredericPietersImogeneLoggerJadeSijbenLauraPeetersMaikelTeunissenMariëlBlok-HoosMarijeKetelsMarjoleinHenkensMichielSpanjersMireilleJacob-DolsMoniquede HoogtPatrickHoubenRikGoldhoornRobert-Janvan GorpRoosHinsenveldWouterJansenJosien
[Category] update2024,
[Article Type] Original research
[Source] PMC
Objectives To evaluate the relationship among dysnatraemia at hospital presentation and duration of admission, risk of intensive care unit (ICU) admission and all-cause mortality and to assess the underlying pathophysiological mechanism of hyponatraemia in patients with COVID-19. Our hypothesis is that both hyponatraemia and hypernatraemia at presentation are associated with adverse outcomes. Design Observational study. Setting Secondary care; 11 Dutch hospitals (2 university and 9 general hospitals). Participants An analysis was performed within the retrospective multicentre cohort study COVIDPredict. 7811 patients were included (60% men, 40% women) between 24 February 2020 and 9 August 2022. Patients who were ≥18 years with PCR-confirmed COVID-19 or CT with COVID-19 reporting and data system score≥4 and alternative diagnosis were included. Patients were excluded when serum sodium levels at presentation were not registered in the database or when they had been transferred from another participating hospital. Outcome measures We studied demographics, medical history, symptoms and outcomes. Patients were stratified according to serum sodium concentration and urinary sodium excretion. Results Hyponatraemia was present in 2677 (34.2%) patients and hypernatraemia in 126 (1.6%) patients. Patients with hyponatraemia presented more frequently with diarrhoea, lower blood pressure and tachycardia. Hyponatraemia was, despite a higher risk for ICU admission (OR 1.27 (1.11–1.46; p<0.001)), not associated with mortality or the risk for intubation. Patients with hypernatraemia had higher mortality rates (OR 2.25 (1.49–3.41; p<0.001)) and were at risk for ICU admission (OR 2.89 (1.83–4.58)) and intubation (OR 2.95 (1.83–4.74)). Conclusions Hypernatraemia at presentation was associated with adverse outcomes in patients with COVID-19. Hypovolaemic hyponatraemia was found to be the most common aetiology of hyponatraemia. Hyponatraemia of unknown aetiology was associated with a higher risk for ICU admission and intubation and longer duration of admission.
All Keywords
【저자키워드】 COVID-19, Infectious diseases, internal medicine,