Background: Fatigue can be a disabling MS symptom with no effective treatment options. Objectives: Determine whether a low-fat diet improves fatigue in people with MS (PwMS). Methods: We conducted a 16-week randomized controlled trial (RCT) and allocated PwMS to a low-fat diet (active, total daily fat calories not exceeding 20%) or wait-list (control) group. Subjects underwent two weeks of baseline diet data collection [24-hour diet recalls (24HDR)], followed by randomization. The active group received two weeks of nutrition counseling and underwent a 12-week low-fat diet intervention. One set of three 24HDRs at baseline and week 16 were collected. We administered a food frequency questionnaire (FFQ) and Modified Fatigue Impact Scale (MFIS) every 4 weeks. The control group continued their pre-study diet and received diet training at the study completion. Results: We recruited 39 PwMS [20 – active; 19 – control]. The active group decreased their daily caloric intake by 11% (95% CI: −18.5%, −3.0%) and the mean MFIS by 4.0 (95% CI −12.0, 4.0) compared to the control (intent to treat). Sensitivity analysis strengthened the association with a mean MFIS difference of −13.9 (95% CI: −20.7, −7.2) Conclusions: We demonstrated a significant reduction in fatigue with a low-fat dietary intervention in PwMS.
【저자키워드】 Randomized controlled trial, clinical trial, multiple sclerosis, fatigue, actigraphy, Low-fat diet,