Keitany et al. demonstrate a novel antibody discovery method yielding large numbers of spike-reactive antibodies from B cells of individuals infected with COVID19. These antibodies have diverse sequences and MOAs, including S2-binders reactive across betacoronaviruses that neutralize by blocking membrane fusion. A tested subset provides potent protection in animal models.
All Keywords
【저자키워드】 SARS CoV-2, antibodies, Cell fusion, broadly neutralizing antibodies, antibody secreting cells, High throughput sequencing, BCR pairSEQ, S2 antibodies, TruAB Discovery,
【저자키워드】 SARS CoV-2, antibodies, Cell fusion, broadly neutralizing antibodies, antibody secreting cells, High throughput sequencing, BCR pairSEQ, S2 antibodies, TruAB Discovery,