In this study, we found that interleukin‐7 greatly improved T cell development and expanded the T cell receptor repertoire after thymus implantation in athymic nude mice. Thymus implantation is a recently approved therapy for congenital athymia; however, naive T cells fail to fully develop. Our findings indicate that developing strategies to incorporate interleukin‐7 may potentially improve outcomes of clinical thymus implantation.
All Keywords
【저자키워드】 T cells, Translational immunology, thymus, Transplant immunology, Primary immunodeficiency disorders,
【저자키워드】 T cells, Translational immunology, thymus, Transplant immunology, Primary immunodeficiency disorders,