Sims et al. integrate experiments with β cell-specific knockout mice and human islets in vitro alongside a multicenter clinical trial to show that inhibition of polyamine biosynthesis is a safe approach to protect β cell function in individuals with recent-onset type 1 diabetes.
All Keywords
【저자키워드】 Type 1 diabetes, Trial, prevention, polyamines, Disease modification, islet, β cell, ornithine decarboxylase, α-difluoromethylornithine, β cell stress,
【저자키워드】 Type 1 diabetes, Trial, prevention, polyamines, Disease modification, islet, β cell, ornithine decarboxylase, α-difluoromethylornithine, β cell stress,