Burke and colleagues demonstrated that following intramuscular administration of mRNA-lipid nanoparticles, mRNA was present for 24 h and then rapidly degraded. mRNA and expressed protein were detected in injection site tissue-resident and infiltrating immune cells and draining lymph nodes. mRNA-lipid nanoparticle vaccine trafficking and resulting protein expression are crucial for effective immune response.
All Keywords
【저자키워드】 Vaccine, Lipid nanoparticles, delivery, mRNA, Trafficking, intramuscular, MT: Delivery Strategies,
【저자키워드】 Vaccine, Lipid nanoparticles, delivery, mRNA, Trafficking, intramuscular, MT: Delivery Strategies,