[저자] Angela Koech, Geoffrey Omuse, Alex G. Mugo, Isaac G. Mwaniki, Joseph M. Mutunga, Moses W. Mukhanya, Onesmus Wanje, Grace M. Mwashigadi, Geoffrey G. Katana, Rachel Craik, Peter von Dadelszen, Kirsty Le Doare, Marleen Temmerman, periCOVID-AfricaFreyneBridgetKawazaKondwaniLissauerSamanthaSommerfeltHalvorEttiMelanieMusokePhilippaMboiziRobertCoseStephenNankabirwaVictoriaHookhamLaurenOumaJosephRukondoGordonCochetMadeleineVoyseyMerrynCantrellLiberty, Bridget Freyne, Kondwani Kawaza, Samantha Lissauer, Halvor Sommerfelt, Melanie Etti, Philippa Musoke, Robert Mboizi, Stephen Cose, Victoria Nankabirwa, Lauren Hookham, Joseph Ouma, Gordon Rukondo, Madeleine Cochet, Merryn Voysey, Liberty Cantrell, The PRECISE NetworkOkiroPatriciaJumaConsolataOchiengMarvinMwadimeEmilySeveneEsperançaTchavanaCorssinoMacuacuaSalesioValaAnifaBoeneHelenaQuimiceLazaroMaculuveSoniaMaceteEusebioMandomandoInacioCarillhoCarlaD’AlessandroUmbertoRocaAnnaJahHawanatuPrenticeAndrewMartinez-AlvarezMelisaDialloBrahimaSesayAbdulSusoSambouNjieBaboucarrTourayFatimaIdrisYahayaKongiraFatoumataNdureModou F.S.GabbidonGibrilGibbaLawrenceBahAbdoulieBahYorroMageeLaura A.MistryHitenVolvertMarie-LaureMendyThomasPostonLucillaSandallJaneTribeRachelMooreSophieSalisburyTatiana T.RussellDonnaMakangaPrestige T.MakachaLibertyMlamboReasonPapageorghiouArisNobleAlisonBlencoweHannahFilippiVeroniqueLawnJoySilverMattWaiswaJosephGazeleyUrsulaCartwrightJudithWhitleyGuyKrishnaSanjeevVidlerMarianneLiJing (Larry)BoneJeffKinshellaMai-Lei (Maggie) WTuDomenaSandhuAshPickerillKellyBarrattBen, Patricia Okiro, Consolata Juma, Marvin Ochieng, Emily Mwadime, Esperança Sevene, Corssino Tchavana, Salesio Macuacua, Anifa Vala, Helena Boene, Lazaro Quimice, Sonia Maculuve, Eusebio Macete, Inacio Mandomando, Carla Carillho, Umberto D’Alessandro, Anna Roca, Hawanatu Jah, Andrew Prentice, Melisa Martinez-Alvarez, Brahima Diallo, Abdul Sesay, Sambou Suso, Baboucarr Njie, Fatima Touray, Yahaya Idris, Fatoumata Kongira, Modou F.S. Ndure, Gibril Gabbidon, Lawrence Gibba, Abdoulie Bah, Yorro Bah, Laura A. Magee, Hiten Mistry, Marie-Laure Volvert, Thomas Mendy, Lucilla Poston, Jane Sandall, Rachel Tribe, Sophie Moore, Tatiana T. Salisbury, Donna Russell, Prestige T. Makanga, Liberty Makacha, Reason Mlambo, Aris Papageorghiou, Alison Noble, Hannah Blencowe, Veronique Filippi, Joy Lawn, Matt Silver, Joseph Waiswa, Ursula Gazeley, Judith Cartwright, Guy Whitley, Sanjeev Krishna, Marianne Vidler, Jing (Larry) Li, Jeff Bone, Mai-Lei (Maggie) W Kinshella, Domena Tu, Ash Sandhu, Kelly Pickerill, Ben Barratt
[Category] update2024,
[Article Type] Public Health Original Research
[Source] PMC
Background Seroprevalence studies are an alternative approach to estimating the extent of transmission of SARS-CoV-2 and the evolution of the pandemic in different geographical settings. We aimed to determine the SARS-CoV-2 seroprevalence from March 2020 to March 2022 in a rural and urban setting in Kilifi County, Kenya. Methods We obtained representative random samples of stored serum from a pregnancy cohort study for the period March 2020 to March 2022 and tested for antibodies against the spike protein using a qualitative SARS-CoV-2 ELISA kit (Wantai, total antibodies). All positive samples were retested for anti-SARS-CoV-2 anti-nucleocapsid antibodies (Euroimmun, ELISA kits, NCP, qualitative, IgG) and anti-spike protein antibodies (Euroimmun, ELISA kits, QuantiVac; quantitative, IgG). Results A total of 2,495 (of 4,703 available) samples were tested. There was an overall trend of increasing seropositivity from a low of 0% [95% CI 0–0.06] in March 2020 to a high of 89.4% [95% CI 83.36–93.82] in Feb 2022. Of the Wantai test-positive samples, 59.7% [95% CI 57.06–62.34] tested positive by the Euroimmun anti-SARS-CoV-2 NCP test and 37.4% [95% CI 34.83–40.04] tested positive by the Euroimmun anti-SARS-CoV-2 QuantiVac test. No differences were observed between the urban and rural hospital but villages adjacent to the major highway traversing the study area had a higher seroprevalence. Conclusion Anti-SARS-CoV-2 seroprevalence rose rapidly, with most of the population exposed to SARS-CoV-2 within 23 months of the first cases. The high cumulative seroprevalence suggests greater population exposure to SARS-CoV-2 than that reported from surveillance data.
All Keywords
【저자키워드】 COVID-19, antibodies, SARS-CoV-2, Seroprevalence, Pregnancy, Kenya,