Exploring the conformational dynamics of the SARS-CoV-2 SL4 hairpin by combining optical tweezers and base analogues †

Published on
Journal: Nanoscale
[저자] Vinoth Sundar Rajan, Anna Wypijewska del Nogal, Sune Levin, L. Marcus Wilhelmsson, Fredrik Westerlund
[Category] update2024,
PMC URL    Pubmed URL    DOI URL    [DOI] 10.1039/d3nr04110g    
[Article Type] Chemistry
[Source] PMC

We characterize the stability, conformational dynamics, (un)folding pathways, as well as identify a promising drug–target site within the SL4 hairpin of the SARS-CoV-2 by combining base analogues and optical tweezers.

All Keywords