A broadly reactive antibody targeting the N-terminal domain of SARS-CoV-2 spike confers Fc-mediated protection

Published on
Journal: Cell Reports Medicine
[저자] Lucas J. Adams, Laura A. VanBlargan, Zhuoming Liu, Pavlo Gilchuk, Haiyan Zhao, Rita E. Chen, Saravanan Raju, Zhenlu Chong, Bradley M. Whitener, Swathi Shrihari, Prashant N. Jethva, Michael L. Gross, James E. Crowe, Sean P.J. Whelan, Michael S. Diamond, Daved H. Fremont
[Category] update2024,
PMC URL    Pubmed URL    DOI URL    [DOI] 10.1016/j.xcrm.2023.101305    
[Article Type] Article
[Source] PMC

Adams et al. describe a neutralizing mAb, SARS2-57, that efficiently binds cells infected by many SARS-CoV-2 variants and confers Fc-mediated protection in mice. Structural analysis demonstrates that SARS2-57 targets the NTD, revealing the basis for variant recognition and immune evasion.

All Keywords
【저자키워드】 SARS-CoV-2, Neutralizing antibodies, variants of concern, cryo-EM, B cell epitope mapping,