High diagnostic accuracy of quantitative SARS-CoV-2 spike-binding-IgG assay and correlation with in vitro viral neutralizing activity

Published on
Journal: Heliyon
[저자] Noriko Iwamoto, Yuki Takamatsu, Yusuke Asai, Kiyoto Tsuchiya, Kouki Matsuda, Yusuke Oshiro, Natsumi Inamura, Mari Terada, Takashi Nemoto, Moto Kimura, Sho Saito, Shinichiro Morioka, Maeda Kenji, Hiroaki Mitsuya, Norio Ohmagari
[Category] update2024,
PMC URL    Pubmed URL    DOI URL    [DOI] 10.1016/j.heliyon.2024.e24513    
[Article Type] Research Article
[Source] PMC

Highlights • Quantified SARS-CoV-2 Spike-binding-IgG correlates with neutralizing activity. • Rational cut-off values enhance the diagnostic accuracy of serological tests. • Quantitative anti-SARS-CoV-2 Spike-immunoglobulin G test is useful diagnostically. • COVID 19-convalescent individuals possess serum virus-neutralizing activity.

All Keywords
【저자키워드】 COVID-19, neutralizing antibody, SARS-CoV-2, diagnostic tools, Quantitative anti-SARS-CoV-2-spike-IgG antibody test,