Chen et al. identify and characterize SARS-CoV-2-derived CD4^{+} T cell epitopes restricted by the common HLA-DR1 allotype. Biophysical analyses suggest that peptide-HLA-DR1 affinity is not the key determinant of immunogenicity, and crystallographic structures of HLA-bound variant epitopes demonstrate two different mechanisms of escape from memory CD4^{+} T cells.
All Keywords
【저자키워드】 COVID-19, SARS-CoV-2, coronavirus, T cells, Crystallography, Immune escape, CD4+ T cells, immune memory, Antigen presentation, HLA class II,
【저자키워드】 COVID-19, SARS-CoV-2, coronavirus, T cells, Crystallography, Immune escape, CD4+ T cells, immune memory, Antigen presentation, HLA class II,