d -α-tocopheryl polyethylene glycol 1000 succinate surface scaffold polysarcosine based polymeric nanoparticles of enzalutamide for the treatment of colorectal cancer: In vitro, in vivo characterizations

Published on
Journal: Heliyon
[저자] Disha Shah, Sankha Bhattacharya, Girdhari Lal Gupta, Ketan Vinayakrao Hatware, Arinjay Jain, Laxmi Manthalkar, Niraj Phatak, Putrevu Sreelaya
[Category] update2024,
PMC URL    Pubmed URL    DOI URL    [DOI] 10.1016/j.heliyon.2024.e25172    
[Article Type] Research Article
[Source] PMC

Highlights • Enzalutamide (ENZ) scaffolded PLGA-polysarcosine (PSAR) nanoparticles were fabricated with outer coating of TPGS for solubility enhancement. • ENZ-PLGA-PSAR-TPGS NPs characterized by SEM, TEM, DSC, XRD, FT-IR. • In vitro anti-cancer cyto-toxicity evaluation performed for ENZ-PLGA-PSAR-TPGS NPs in HCT-116 cell lines. • Haemolysis, Platelet aggregation, Acute toxicity conducted to analyze biocompatibility. • Anti-Cancer activity of ENZ-PLGA-PSAR-TPGS NPs evaluated by Apoptosis, MMP, ROS, wound healing, DNA fragmentation studies.

All Keywords
【저자키워드】 enzalutamide, box-behnken design, Cell cycle analysis, TPGS, DNA fragmentation assay, HCT 116,