Highlights • Vidofludimus calcium and pyrazofurin are novel anti-HEV entities. • Both drugs exert anti-HEV effect through depletion of pyrimidine nucleotide pool. • Both drugs robustly inhibit HEV replication in human primary liver organoids. • Both drugs effectively inhibit ribavirin treatment failure-associated HEV mutants. • Vidofludimus calcium and pyrazofurin synergize IFN-α against HEV.
All Keywords
【저자키워드】 Drug repurposing, pyrimidine biosynthesis, Hepatitis E virus (HEV), Pyrazofurin, Vidofludimus calcium,
【저자키워드】 Drug repurposing, pyrimidine biosynthesis, Hepatitis E virus (HEV), Pyrazofurin, Vidofludimus calcium,