Highlights • HBV replicates in a closed-loop pattern without a defined beginning or end. • cccDNA is the key rate-limiting node in this loop that must be cleared to eliminate HBV. • Anti-HBV strategies can be classified into two categories based on their impact on cccDNA dynamics. • Accelerating cccDNA decay is essential to cure chronic hepatitis B.
All Keywords
【저자키워드】 Treatment, Dynamics, Strategy, hepatitis B, cccDNA, functional cure,
【저자키워드】 Treatment, Dynamics, Strategy, hepatitis B, cccDNA, functional cure,