Plain Language Summary Primaquine and tafenoquine are 8-aminoquinolines used to provide radical cure from dormant stages of malaria vivax; recurrence from dormant malaria parasite causes morbidity and mortality especially in women who are not eligible for treatment while pregnant and breastfeeding. Subjects with glucose-6-phosphate dehydrogenase (G6PD) deficiency are susceptible to dose-dependent drug-induced haemolysis when treated with several drugs including antibiotics and 8-aminoquinolines. G6PD testing is necessary before use of these drugs. Adult normal reference values for G6PD enzymatic activity exist for adults and are used to provide safe radical cure with different regimens of primaquine and tafenoquine. We have collected data in infants to establish normal reference values of G6PD enzymatic activity in infants aged 2-6 months. These results will be used in future to carry out clinical trials where breast-feeding women of a malaria endemic area will be treated with 8-aminoquinolines. Inclusion of mothers and their babies will be based on already established reference values in adult and these newly established values for infants. An added benefit for infants is that age-specific reference values established with this study will be used more widely to provide safer antibiotic treatment.
【저자키워드】 Infants, G6PD deficiency, Plasmodium vivax, Malaria elimination, G6PD testing, paediatric G6PD reference values,