The NSP3 protein of SARS-CoV-2 binds fragile X mental retardation proteins to disrupt UBAP2L interactions

Published on
Journal: EMBO Reports
[저자] Dimitriya H Garvanska, R Elias Alvarado, Filip Oskar Mundt, Richard Lindqvist, Josephine Kerzel Duel, Fabian Coscia, Emma Nilsson, Kumari Lokugamage, Bryan A Johnson, Jessica A Plante, Dorothea R Morris, Michelle N Vu, Leah K Estes, Alyssa M McLeland, Jordyn Walker, Patricia A Crocquet-Valdes, Blanca Lopez Mendez, Kenneth S Plante, David H Walker, Melanie Bianca Weisser, Anna K Överby, Matthias Mann, Vineet D Menachery, Jakob Nilsson
[Category] update2024,
PMC URL    Pubmed URL    DOI URL    [DOI] 10.1038/s44319-023-00043-z    
[Article Type] Article
[Source] PMC

The SARS-CoV-2 NSP3 protein binds directly to fragile X mental retardation proteins (FMRPs) to support viral replication. NSP3 binding disrupts FMRP interaction with the stress granule protein UBAP2L, thereby preventing FMRP localization to these structures.

All Keywords
【저자키워드】 SARS-CoV-2, Nsp3, stress granules, Signal transduction, Microbiology, Virology & Host Pathogen Interaction, Fragile X Syndrome, UBAP2L,