Highlights • HBsAg accumulation induces ER stress and hepatocarcinogenesis in vivo . • After HBsAg challenge, ATF4 and ATF6 downregulate the expression of LAMP2. • Reduced LAMP2 worsens ER stress-related autophagic flux and promotes proliferation. • ER stress inhibitors reverse HBsAg-reduced LAMP2 and suppress proliferation.
All Keywords
【저자키워드】 lysosome, Liver cancer, tumorigenesis, cellular homeostasis, HBV surface protein, incomplete autophagy,
【저자키워드】 lysosome, Liver cancer, tumorigenesis, cellular homeostasis, HBV surface protein, incomplete autophagy,