Mucosal vaccine-induced cross-reactive CD8 + T cells protect against SARS-CoV-2 XBB.1.5 respiratory tract infection

Published on
Journal: Nature Immunology
[저자] Baoling Ying, Tamarand L. Darling, Pritesh Desai, Chieh-Yu Liang, Igor P. Dmitriev, Nadia Soudani, Traci Bricker, Elena A. Kashentseva, Houda Harastani, Saravanan Raju, Meizi Liu, Aaron G. Schmidt, David T. Curiel, Adrianus C. M. Boon, Michael S. Diamond
[Category] update2024,
PMC URL    Pubmed URL    DOI URL    [DOI] 10.1038/s41590-024-01743-x    
[Article Type] Article
[Source] PMC

Here, the authors enhance their nasally delivered chimpanzee adenoviral-vectored SARS-CoV-2 vaccine with an Omicron-matched vaccine (ChAd-SARS-CoV-2-BA.5-S) that stimulates mucosal immunity in mice and hamsters and shows cross-reactive CD8^{+} memory T cell-driven protection against antigenically distant strains.

All Keywords
【저자키워드】 SARS-CoV-2, viral infection, RNA vaccines, Immunological memory,