Rip and colleagues composed nanoparticles with biodegradable poly(amido)amine-based polymers and mRNA payload that were shown to efficiently deliver influenza hemagglutinin mRNA to target tissues and elicit protective immune responses in a relevant ferret influenza challenge model. These data highlight the importance of polymeric nanoparticles as efficient alternative delivery technology for lipid nanoparticles.
All Keywords
【저자키워드】 Vaccine, Influenza, Polymer, Nanoparticles, mRNA, hemagglutinin, ferrets, MT: Delivery Strategies, non-viral,
【저자키워드】 Vaccine, Influenza, Polymer, Nanoparticles, mRNA, hemagglutinin, ferrets, MT: Delivery Strategies, non-viral,