The authors find that small circular DNA nanostructures which partially match gRNA sequences only minimally activate Cas12a. They report AutoCAR (Autocatalytic Cas12a Circular DNA Amplification Reaction) which allows a single nucleic acid target to activate multiple ribonucleoproteins, and increases reporter cleavage rates.
All Keywords
【저자키워드】 DNA, CRISPR-Cas9 genome editing, Biocatalysis,
【저자키워드】 DNA, CRISPR-Cas9 genome editing, Biocatalysis,