The COVID-19 pandemic has been associated with a tremendous financial and social impact. The pressure on healthcare systems worldwide has increased with each pandemic wave. The present study assesses the impact of the COVID-19 pandemic on healthcare-derived costs of critically ill patients during the fourth wave of the COVID-19 pandemic in a tertiary hospital in Romania. We prospectively included patients admitted to a single-centre intensive care unit (ICU) during the fourth wave of the COVID-19 pandemic. Median daily costs were calculated from financial records and divided in three groups: administrative costs, treatment costs and investigation costs. These were then compared to two retrospective cohorts of non-COVID-19 patients admitted to the same ICU during the same time interval in 2020 and 2019. Demographic data and the management of SARS-CoV-2 infection and of associated organ dysfunctions were recorded to identify risk factors for higher costs. Our results show that the COVID-19 pandemic has been associated with a 70.8% increase in total costs compared to previous years. This increase was mainly determined by an increase in medication and medical-device-related costs. We identified the following as risk factors for increased costs: higher degrees of lung involvement, severity of respiratory dysfunction, need for renal replacement therapy and the use of antiviral or immunomodulatory therapy. Costs were higher in patients who had a shorter duration of hospitalization. In conclusion, the COVID-19 pandemic is associated with increased costs for patients, and rapid measures need to be taken to ensure adequate financial support during future pandemic waves, especially in developing countries.
【저자키워드】 COVID-19, intensive care unit, healthcare-associated costs, medication costs, 【초록키워드】 Treatment, pandemic, intensive care, Antiviral, SARS-COV-2 infection, COVID-19 pandemic, severity, lung involvement, hospital, risk factor, ICU, management, Patient, organ dysfunction, Romania, medication, demographic, patients, immunomodulatory therapy, renal replacement therapy, Healthcare system, Support, Critically ill patient, dysfunction, measure, retrospective cohort, duration of hospitalization, identify, calculated, increase in, were recorded, non-COVID-19 patient, 【제목키워드】 Wave, European, Tertiary,