Background Coronavirus disease 2019 (COVID-19) is a global public health concern. Recently, a genome-wide association study (GWAS) was performed with participants recruited from Italy and Spain by an international consortium group. Methods Summary GWAS statistics for 1610 patients with COVID-19 respiratory failure and 2205 controls were downloaded. In the current study, we analyzed the summary statistics with the information of loci and p -values for 8,582,968 single-nucleotide polymorphisms (SNPs), using gene ontology analysis to determine the top biological processes implicated in respiratory failure in COVID-19 patients. Results We considered the top 708 SNPs, using a p -value cutoff of 5 × 10 − 5 , which were mapped to the nearest genes, leading to 144 unique genes. The list of genes was input into a curated database to conduct gene ontology and protein-protein interaction (PPI) analyses. The top ranked biological processes were wound healing, epithelial structure maintenance, muscle system processes, and cardiac-relevant biological processes with a false discovery rate < 0.05. In the PPI analysis, the largest connected network consisted of 8 genes. Through a literature search, 7 out of the 8 gene products were found to be implicated in both pulmonary and cardiac diseases. Conclusion Gene ontology and PPI analyses identified cardio-pulmonary processes that may partially explain the risk of respiratory failure in COVID-19 patients.
【저자키워드】 COVID-19, SARS-CoV-2, Respiratory failure, bioinformatics, Single-nucleotide polymorphisms, Genome-wide association study, 【초록키워드】 coronavirus disease, Coronavirus disease 2019, Diseases, Respiratory failure, SNPs, polymorphism, risk, Gene ontology, Italy, database, International, Ontology, Single-nucleotide polymorphisms, Genome-wide association study, Spain, Control, GWAS, information, epithelial, protein-protein interaction, COVID-19 patients, Analysis, PPI, false discovery rate, global public health, Gene ontology analysis, P -value, participant, Cutoff, p -values, list, wound healing, loci, input, Genes, unique genes, Result, analyzed, recruited, was performed, determine, analysis, gene product, analyses, mapped, implicated, explain, biological processe, curated, downloaded, list of gene, patients with COVID-19, single-nucleotide, 【제목키워드】 Respiratory failure, identification,