Ancestral allele of DNA polymerase gamma modifies antiviral tolerance

Published on
Journal: Nature
[저자] Yilin Kang, Jussi Hepojoki, Rocio Sartori Maldonado, Takayuki Mito, Mügen Terzioglu, Tuula Manninen, Ravi Kant, Sachin Singh, Alaa Othman, Rohit Verma, Johanna Uusimaa, Kirmo Wartiovaara, Lauri Kareinen, Nicola Zamboni, Tuula Anneli Nyman, Anders Paetau, Anja Kipar, Olli Vapalahti, Anu Suomalainen
[Category] update2024,
PMC URL    Pubmed URL    DOI URL    [DOI] 10.1038/s41586-024-07260-z    
[Article Type] Article
[Source] PMC

The POLG1 mutation p.W748S, which is associated with mitochondrial recessive ataxia syndrome, dampens innate immune responses by compromising mtDNA replisome stability, and this explains why a viral infection can trigger the development of the disease and contribute to its variable clinical manifestation.

All Keywords
【저자키워드】 Risk factors, neurodegeneration, Metabolic disorders, RIG-I-like receptors,