The pore-forming toxin pneumolysin is responsible for the high mortality seen in pneumococcal infections unresponsive to antibiotics. In this work, authors report a small molecule inhibitor targeting pneumolysin and related ones as an anti-virulence strategy protecting human cells during infection.
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【저자키워드】 Virtual drug screening, Target validation, Drug discovery and development, Cryoelectron tomography,
【저자키워드】 Virtual drug screening, Target validation, Drug discovery and development, Cryoelectron tomography,