Immunization via the respiratory route is predicted to increase the effectiveness of SARS-CoV-2 vaccines. Here, Kaiser et al. describe a murine pneumonia virus vectored vaccine expressing spike protein, and show that intranasal immunization of male rhesus macaques provides good mucosal and systemic immunogenicity and efficacy.
All Keywords
【저자키워드】 SARS-CoV-2, viral infection, Preclinical research, Live attenuated vaccines,
【저자키워드】 SARS-CoV-2, viral infection, Preclinical research, Live attenuated vaccines,